Exosomes, mitochondrial DNA and microglia: the fateful triangle in autism – Theoharides

PDF Slides: https://www.dropbox.com/s/fkcp6dqgbgw825y/Theoharides%2C%20exosomes%2C%20mtDNA%2C%20microglia%20Chicago%2C%20May%2027%2C%202018%205-2018.pdf?dl=0

Autism Spectrum Disorder (ASD) remains without distinct pathogenesis and effective treatment. Extracellular vesicles (EVs or exosomes) are secreted in blood or other biological fluids by diverse cell types

EVs are generated either from the cell when multivesicular bodies (MVBs) fuse with the plasma membranes or they are released directly from the plasma membrane.3 EVs can be isolated from serum, plasma, urine and other biological fluids and have been shown to contain RNA, DNA, lipids or proteins that are delivered to the surrounding cells or carried to distal sites. EVs have been implicated in brain disorders, but their presence in ASD has not been investigated.

We isolated EVs from children with ASD (n