Seizures & EEG Abnormalities in Autism: Clinical Significance & Implications for Treatment-Aung Din

Apple Keynote Slides: https://www.dropbox.com/s/ach8md4wp0panj5/2018%20Autism%20One-Seizures%20and%20EEG%20.key?dl=0

Seizures of differing varieties are frequently associated with autism spectrum disorder, ASD. 30-40% of patients with ASD may have clinical seizures and on anticonvulsants. Many more exhibit or experience episodic behavioral and other activity suggestive of paroxysmal dysfunction in brain electrical activity: agitation, attentional and focus problems, sudden outbursts, mood swings; and invountary movements such as flailing, jeking and twitching.
Signs and symptoms of ASD suggest problems in brain signal processing and output from abnormalities in neurochemical and electrical function. These may be reflected in the electroencephalogram, EEG. EEG is objective indication of brain electrical activity, measured through electrodes placed on the skull. However, a “normal” EEG does not necessarily indicate there is not an electrical problem as episodes, such as seizures and other abnormal electrical activity may be episodic, occurring intermittently and not caught on a routine 30-45 minute recording. If abnormal brain electrical discharges are suspected as basis for episodic clinical symptoms, a 72-hour ambulatory EEG should be considered.
The author will present his clnical experience as a neurologist evaluating 30 consecutive ASD patients, age 2-25, with EEG monitoring. All had abnormal baseline EEG’s; 60% with epileptiform characteristics. All baseline EEG’s showed varying degrees of improvement within 5 minutes of Direct EffectsTM cannabidiol, CBD, cream application at back of neck.Over 85% patients showed improvement in clinical symptoms and behavior within 10-15 minutes after CBD and continued therapy long term. Some patients required addition of a systemic cannabinoid while others needed to also remain on tradtional pharmaceuticals.
A case presentation outlining the importance of EEG in evaluating ASD symptoms will be presented.

Ronald Aung-Din, MD